(Not joking)
It's really not that strange within the context of the culture. Or, Japanese culture, at least.
http://en.wikipedia.org/wiki/Bish%C5%8Dnen (specifically, http://en.wikipedia.org/wiki/Bish%C5%8Dnen#Popular_culture ) talks about "boy bands" comprised entirely of androgynous young men:
In particular, Japan's largest male talent agency, Johnny & Associates Entertainment Company specializes only in producing male Tarento idols. Accepted into Johnny & Associates in their early teens, these boys, collectively known as 'Johnnys', are trained and promoted to become the next leading singing-acting-commercially successful hit sensations. Almost all can be classifed as bishōnen, exhibiting the same physically feminine features combined with a sometimes deliberately ambivalent sexuality or at the very least, a lack of any hint of a relationship in order to maintain their popular availability.
"A similar, South Korean aesthetic has been noted in the kkon-mi-nam ('flowery pretty boy')."
Doesn't seem like too far of a stretch to mix up this "bishōnen" theme, or whatever you want to call it (my brain is on vacation), with a reverse of it, in the form of androgynous asexual female. We have seen the American counterpart several times with movies of androgynous girls hanging out with a bunch of manly men, or the opposite with men dressed up rather unconvincingly as ugly women and hanging out with a bunch of airheaded chicks. Geez. Now that I've put it that way, the soap opera version sounds far more sophisticated. Yay America.
Boys Don't Cry is probably the best we have in that genre. The bad ones are stuff like White Chicks or one of those Eddie Murphy or Martin Lawrence ones. And there was that one in the 80s with the girl and the football team and hey that sounds more like a porno - but it was the 80s, so, yeah.
Anyhow! Show sounds sorta interesting!