Rambo V (what the what? 2011)

http://www.imdb.com/title/tt1206885/

In the near future, illegal medical experiments in the Pacific Northwest have created this nearly indestructible creature of incredible cunning and savagery. It goes on a rampage through the ranks of the research stations. To cover their blunder, the government sends out an elite team of special-operations warriors. The gang is led by John Rambo, a Vietnam War veteran born out of time and the best tracker in the world. Meanwhile, U.S. marshals are on the trail of the secret and the cover-up, intervening in the action in an unexpected way.

With Sylvester and Mickey Rourke. Of course!